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Mamidala, Estari
- Seroprevalence of HIV /AIDS Infection Among Tribals in Rural Areas of Adilabad District (A.P.) India
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1 Reproductive Physiology Unit, Department of Zoology, Kakatiya University, Warangal - 506 009 (A.P.), IN
1 Reproductive Physiology Unit, Department of Zoology, Kakatiya University, Warangal - 506 009 (A.P.), IN
Source
Asian Journal of Bio Science, Vol 1, No 2 (2006), Pagination: 32-34Abstract
Seroprevalence of Human Immunodeficiency Virus (HIV) infection was carried out among tribals in rural areas of Adilabad District from February 2002 to December 2004. 390 individuals were counseled and screened for HIV status. Out of 390 individuals 6.6% (26) of seroprevalence is found in Tribal areas of Adilabad district of which 57% (15) were females 43% (11) are males. Women are biologically more susceptible to HIV infection than men. The higher prevalence rate was among the 21-35 years age group. The seroprevalence was high among married persons as against unmarried tribals. Our studies indicate that, HIV infection was highest among the illiterates (26%). But very less in well educated tribal people (7%). Most of the HIV infected individuals are laborers (26%) and women sex workers (19%), clinical manifestations are found individuals with STD (Sexually Transmitted Diseases) (23%). Our finding provide evidence to the spread and stabilization of HIV epidemic into all the risk rural population is the study area to Adilabad District. Higher prevalence was observes in villages close to the high ways. This is a serious public health issue as rural populations have less access to diagnosis and treatment. The higher rate in rural areas requires greatly increased efforts for HIV education outside cities and towns.Keywords
HIV, Aids, Infection, Tribal.- An In Silico Approach for Identification of Inhibitors as a Potential Therapeutics Targeting SARS-Cov-2 Protease
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Authors
Affiliations
1 Infectious Diseases Research Lab, Department of Zoology, Kakatiya University, Hanamkonda, Warangal – 506009, Telangana, IN
1 Infectious Diseases Research Lab, Department of Zoology, Kakatiya University, Hanamkonda, Warangal – 506009, Telangana, IN
Source
Asian Journal of Pharmaceutical Research and Health Care, Vol 12, No 1 (2020), Pagination: 3-9Abstract
SARS-CoV-2 caused COVID-19 which is pandemic and is a global health emergency. Protease is the drug target for corona viruses and this enzyme processes the production of polyproteins from the viral RNA. Objective of this study is to find the inhibitors against SARS-Cov-2 protease. AutoDock 4.2 was used for docking calculations. To check different molecules, test ligands like lopinavir, ritonavir (retroviral drugs) and hydroxychloroquine (anti-malarial drug) were docked against our target enzyme protease retrieved from Protein Data Bank. With respect to docking free binding energy, it is revealed that, Hydroxychloroquine has the lowest binding energy followed by Ritonavir and Lopinavir binds significantly to target enzyme protease. The results of this study provide a solid base for the use of Hydroxychloroquine against COVID-19 treatment. The interactions from structural models at the protease active site of virus can offer a valuable guide for more strategies for structure-based medications and the development of more operative inhibitors of SARS-CoV-2 protease.Keywords
COVID-19, Hydroxychloroquine, In Silico, Lopinavir, Ritonavir, SARS-Cov-2i Protease.References
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